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. 2023 Apr 6;14:1138162. doi: 10.3389/fphys.2023.1138162

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Copyright © 2023 Meng, Geng, Jin, Teng, Xiao, Wu and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exercise preserves senescent vascular function. Exercise counteracts endothelial senescence through anti-oxidative and anti-inflammatory mechanisms and by reducing lipid peroxidation. Physical activity also increases the expression of IL-10, IL-15, adiponectin, Fstl1, SIRT1, HO-1, SOD, IGF-1/PI3K/p-Akt, eNOS, TERT, TRFs, and Chk2. Physical exercise improves the function of senescent VSMCs by inhibiting the expression of MAPK, Ang II, MMPs, ROS, and iNOS. And exercise facilitates the productions of Akt, α-SM-actin, calponin, osteopontin, and ACE2/Ang 1-7/MasR.