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. 2023 Apr 20;21(4):e3002078. doi: 10.1371/journal.pbio.3002078

Fig 6. Loss of DSCAM impairs GABAergic synaptic transmission to neocortical PyNs.

Fig 6

(A) Representative traces of mIPSCs from PyNs in layer II/III of the ACC in DSCAM+/− and DSCAM−/− brain slices. (B, C) Quantification of mIPSC frequency (B) and amplitude (C). For each mouse, 3–5 PyNs were recorded. A total of 5 DSCAM+/− and 4 DSCAM−/− mice were analyzed. N: 16 for DSCAM+/−, and 13 for DSCAM−/−. (D) Representative traces of sIPSCs from PyNs in layer II/III of ACC in DSCAM+/− and DSCAM−/− brain slices. (E, F) Quantification of sIPSC frequency (E) and amplitude (F). Approximately 3–5 PyNs were recorded for each mouse. A total of 5 DSCAM+/− and 4 DSCAM−/− mice were analyzed. N: 17 for DSCAM+/−, 14 for DSCAM−/−. Student t test. *: p < 0.05. The data underlying this Figure can be found in https://doi.org/10.5281/zenodo.7714234. ACC, anterior cingulate cortex; DSCAM, Down syndrome cell adhesion molecule; mIPSC, miniature inhibitory postsynaptic current; PyN, pyramidal neuron; sIPSC, spontaneous inhibitory postsynaptic current.