Table 1.

Composition of tick saliva

Constituent	Examples
Water	Excess water from host bloodmeal
Ions	Na+, Cl− (excess ions from host bloodmeal)
Non-peptidic molecules	Adenosine, prostaglandins, endocannabinoids, microRNAs
Tick peptides	Variegins, hyalomins, madanins
Tick proteins	Chitinases, mucins, ixostatins, cystatins, defensins, glycine-rich, hyaluronidases, Kunitz-type proteins, lipocalins, metalloproteases
Host proteins	Immunoglobulins, haptoglobin, transferrin
Exosomes	May contain microRNA, peptides, proteins