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. 2023 Apr 20;79(6):723–751. doi: 10.1007/s00228-023-03486-4

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© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Scheme 2 — Reagents and conditions: a H₂SO₄, MeOH; b NBS, MeCN; c H₂SO₄, NaNO₂, MeOH; d diphenylmethanimine, (S)-BINAP, Pd₂(dba)₃; e NH₃.H₂O; f NaNO₂, HF-Py; g NaI, TMSCl; h NaNO₂, AcOH, − 10° to r.t.; i H₂, Pd/Si, EtOH, 60 °C, flow reactor; j 28% NH₃ in H₂O, r.t.; k 45% NaOH, 39% glyoxal, − 10 °C to r.t.; l Br₂, MeOH, MeCN, 30 °C, flow reactor; m KF, TBAB, DMSO, 60 °C; n AcONa, H₂O, toluene, DMSO, 50 °C; and o H₂SO_4conc, H₂O, NaOH solution, 50 °C