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. Author manuscript; available in PMC: 2023 Apr 20.
Published in final edited form as: J Med Chem. 2021 Dec 15;64(24):18025–18053. doi: 10.1021/acs.jmedchem.1c01382

Figure 11.

Figure 11.

Compound 44e induces regulated autophagy in TNBC cells. (A) MDA-MB-231 and MDA-MB-468 cells were transfected with GFP-mRFP-LC3 adenovirus, following co-incubation with 44e (5 μM) in the presence or absence of BafA1 (10 nM). Scale bar, 10 μm. (B, C) Expression levels of Beclin-1, LC3, and p62 in MDA-MB-231 and MDA-MB-468 cells treated with 5 μM 44e, analyzed by Western blotting. GAPDH was used as load control. Error bar shows SD; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 compared with the control groups.