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. Author manuscript; available in PMC: 2023 Apr 20.
Published in final edited form as: J Med Chem. 2021 Dec 15;64(24):18025–18053. doi: 10.1021/acs.jmedchem.1c01382

Scheme 1a.

Scheme 1a

aReagents and conditions: (a) pyridine, DBU, 80 °C, 1.5 h; (b) pyridine, KOH, 50–80 °C, 2 h; (c) HOAc, 1% H2SO4, 90–110 °C, 2 h; (d) dry toluene, Lawesson’s reagent, 110 °C, 4 h.