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. Author manuscript; available in PMC: 2023 Apr 20.
Published in final edited form as: J Med Chem. 2021 Dec 15;64(24):18025–18053. doi: 10.1021/acs.jmedchem.1c01382

Table 5.

Pharmacokinetic Profile of 44ea

parameter iv (1 mg/kg) po (10 mg/kg)
T1/2 (h) 4.21 ± 0.57 5.14 ± 0.71
Cmax (ng/mL) 237 ± 11 206 ± 6
AUC0–t (ng·h/mL) 579 ± 49 2079 ± 130
AUC0–∞ (ng·h/mL) 588 ± 36 2090 ± 146
Vz (L/kg) 21.1 ± 2.6
CL ((mL/min)/kg) 57.4 ± 1.3
F (%) 32.5
a

All data were obtained by triple testing (mean ± SD) in SD rats.