Table 2. Conversion from Hashimoto to Graves’ disease: reported series of adult patients.
| Number of patients | Mean age | Time to develop hyperthyroidism from hypothyroidism | TSAb Positive (n cases) | TBAb Positive (n cases) | Mean Anti TPO (IU/mL) | |
|---|---|---|---|---|---|---|
| Osorio-Salazar (19)a | 7 | 33 | 36 months | Positive (hyper) | Negative (Hyper) | 414 |
| Takasu and cols.b (21) | 2 | 45 | NA | 110 (Hypo) 900 (Hyper) | 98 (Hypo) 20 (Hyper) |
NA |
| Takeda and cols. (23) | 1 | 48 | 36 months | 93 (Hypo) 163 (Hyper) |
96 (Hypo) 31 (Hyper) |
105 |
| Cho and cols. (24) | 1 | 40 | 12 months | 92 (Hypo) 2703 (Hyper) |
89 (Hypo) 12 (Hyper) |
6400 |
| Takasu and cols. (25) | 8 | 38 | NA | 92 (Hypo) 1490 (Hyper) |
96 (Hypo) 2 (Hyper) |
800 |
| Kraiem and cols. (26) | 1 | 55 | 36 months | 576 (Hyper) | Negative (Hyper) | NA |
| This series | 24 | 36.1 | 38 months | Not done | 24 | 228 |
All patients were treated with LT4.
Values for all thyroid autoantibodies are expressed in μU/mL; Neg, negative (undetectable); NA; not available.
a
In this study TSAb and TBAb values were only registrated in two cases out of seven patients.
b
Only two patients of 34 described by Takasu and cols. (21) had hypothyroidism due to TBAb and a switch to TSAb during hyperthyroidism.
Hyper: hyperthyroidism; hypo: hypothyroidism; TBAb: TSH blocking autoantibodies; TPOAb: autoantibodies to thyroid peroxidase; TSAb: thyroid-stimulating autoantibodies.