Table 1. Characteristics of patients with diabetes classified according to D-Dimer levels.
| Low D-Dimer Group | High D-Dimer Group | p | |
|---|---|---|---|
| Number of individuals (n) | 82 | 43 | |
| Age (years) | 32 (24 – 37) | 35 (30 – 45)* | 0.003 |
| Sex/male (n, %) | 37 (45.1) | 8 (18.6)* | 0.003 |
| BMI (kg/m2) | 24 ± 3 | 23 ± 3 | NS |
| Time of diagnosis (years) | 18 ± 8 | 20 ± 6 | NS |
| Use of antihypertensive (n, %) | 44 (53.7) | 36 (83.7)* | 0.001 |
| Use of statin (n, %) | 22 (26.8) | 18 (41.9) | NS |
| Use of AAS (n, %) | 10 (12.2) | 11 (25.6) | NS |
| HbA1c (%) | 8.5 (7.5 – 9.8) | 8.4 (7.6 – 8.4) | NS |
| Creatinine (mg/dL) | 0.81 (0.66 – 0.92) | 1.02 (0.71 – 1.45)* | 0.001 |
| eGFR (mL/min/1.73 m2) | 112 (91 – 123) | 76 (43 – 104)* | < 0.001 |
| Urea (mg/dL) | 31 ± 7 | 42 ± 17* | < 0.001 |
| Albumin (g/dL) | 4.1 ± 0.4 | 3.8 ± 0.4* | 0.006 |
| Cystatin C (mg/L) | 0.74 (0.64 – 0.85) | 1.11 (0.86 – 1.97)* | < 0.001 |
| UAE (mg/g of creatinine) | 8 (4 – 18) | 44 (6 – 157)* | 0.004 |
| D-Dimer (ng/mL) | 191 (134 – 233) | 484 (381 – 639)* | < 0.001 |
Normally-distributed data were expressed as mean ± SD and compared by ANOVA and T test. Not normally distributed data were expressed as median (percentiles 25% – 75%) and compared by the Kruskal-Wallis H test and Mann-Whitney U test, followed by Bonferroni correction. Categorical variables were expressed as frequencies n (%) and compared using the chi-square test (χ2).
*
p < 0.05 for high D-Dimer group compared to low D-Dimer group.
NS: not significant. BMI: body mass index. UAE: urinary albumin excretion. AAS: acetylsalicylic acid.