Table 1. Chronological evolution of clinical data.
| Age (years) | 45 | 46 | 47 | 48 | 49-52 |
|---|---|---|---|---|---|
| Event | Adrenal | ||||
| Diabetes. Start | Cushing. | Adrenal | |||
| antidiabetic | Start statins | surgery, | Myopathy. | ||
| and | and insulin; | start | Stop statins | ||
| antihypertensi | intensive | hydrocortiso | at 49 | ||
| ve drugs | antihypertensi | ne | |||
| ve therapy | |||||
| BMI | 30.5 | 31.7 | 30.8 | 36.5 | 25-26 |
| BP (mmHg) | 150/90 | 165/109 | 130/9 | 140/93 | 125/80 |
| 0 | |||||
| CPK (UI/L) | - | 176 | 88 | 157 | 378-2500 |
| LDH (U/L) | - | - | - | 556-860 | |
| Glucose (mg/dL) | 250 | 331 | 236 | 137 | 65-91 |
| HbA1C (%) | - | 9.6 | 10.2 | 8.1 | 6-6.1 |
| Triglycerides (mg/ dL) | 164 | 122 | 146 | 254 | 202-214 |
| HDL (mg/dL) | - | 37 | 41 | 30 | 40-40 |
| LDL (mg/dL) | - | 161 | 126 | - | 63-139 |
| Leptin (µg/L) | - | - | 12.7 | 9.9 | 1-8.4 |
| Insulin* (mUI/L) | - | 46.5 | - | - | 43.9 |
| UFC (Ug/24h) | - | 838 | 1014 | - | 36 |
| Cortisol** (ug/dL) | 23 | 30 | 27.4 | 2.2 | 1.6 |
| ACTH | - | 13 | 9 | - | 60 |
BP: blood pressure; UFC: urinary free cortisol;
*
without exogenous insulin:
**
stopping oral corticoid almost 24h before.