Table 4. Familial forms of primary aldosteronism.

	Type I	Type III	Type III
Cause	Hybrid CYP11B1/CYP11B2	Unknown	Germline KCNJ5
Transmission	Autosomal dominant	Autosomal dominant	Autosomal dominant
Genetic diagnosis	Long PCR	No	KCNJ5 sequencing
Hypertension onset	Very often < 20 years	Adulthood	Very often < 10 years
Hypertension severity	Severe to resistant hypertension (normal BP is rare)	Stage 1 to resistant hypertension (normal BP is not often)	Stage 3 to resistant hypertension
Hypokalemia	Rare	Not often	Very often
Aldosterone after dexamethasone	< 4 ng/dL	> 4 ng/dL	> 4 ng/dL
Adrenal CT	Normal	Unilateral or bilateral lesions	Bilateral macronodular hyperplasia
Treatment	Dexamethasone or mineralocorticoid antagonist	Unilateral adrenalectomy or mineralocorticoid antagonist	Bilateral adrenalectomy or mineralocorticoid antagonist

BP: blood pressure. CT: computed tomography.