Table 2. The clinical characteristics, radiological and endocrinologic findings of patients according to histological diagnosis of hypophysitis.
| Symptoms and clinical signs | All (n = 12) | LyHy (n = 4) | GrHy (n = 7) | XantgrHy (n = 1) |
|---|---|---|---|---|
| Headache | 8 (67%) | 2 (50%) | 5 (71%) | 1 (100%) |
| Weight gain | 2 (16%) | 1 (25%) | 1 (14%) | 0 |
| Nausea, vomiting | 3 (25%) | 1 (25%) | 2 (29%) | 0 |
| Visual defects | 4 (33%) | 2 (50%) | 2 (29%) | 0 |
| Amenorrhea/impotence | 5 (41%) | 1 (25%) | 3 (43%) | 1 (100%) |
| Initial radiological signs | ||||
| Pituitary gland swelling | 4 (33%) | 2 (50%) | 2 (29%) | – |
| Compression of the optic chiasm | 4 (33%) | 1 (25%) | 3 (43%) | – |
| Thickened pituitary stalk | 5 (41%) | 2 (50%) | 3 (43%) | – |
| Contrast enhancement heterogeneous | 7 (58%) | 2 (50%) | 4 (57%) | 1 (100%) |
| Initial endocrinological disturbance | ||||
| Diabetes insipidus | 2 (17%) | 1 (25%) | 1 (14%) | – |
| Hypogonadism | 9 (75%) | 3 (75%) | 6 (86%) | – |
| GH deficiency | 6 (50%) | 2 (50%) | 4 (57%) | – |
| Hypothyroidism | 9 (75%) | 4 (100%) | 5 (71%) | – |
| Adrenal insufficiency | 7 (58%) | 4 (57%) | – | |
| Hyperprolactinemia | 1 (8%) | 1 (25%) | 1 (14%) | – |
LyHy: lymphocytic hypophysitis; GrHy: granulomatous hypophysitis; XantgrHy: xanthogranulomatous hypophysitis; GH: growth hormone.