Table 2. Values of odds ratio (OR) and 95% confidence interval (95% CI) for diabetes mellitus type 2 (DM2) and systemic arterial hypertension (SAH) before and after bariatric surgery, according to each gene polymorphism.

Gene Polymorphism	Genotype	n (%)	DM2 Preoperative		SAH Preoperative
			OR (95% CI)	p-value	OR (95% CI)	p-value
GHRL rs26802	CC	35 (10)	1.00	0.921	1.00	0.563
	CA + AA	316 (90)	1.045 (0.436–2.507)		1.244 (0.593–2.609)
GHSR rs572169	GG	211 (60)	1.00	0.547	1.00	0.443
	GA + AA	140 (40)	0.722 (0.250–2.085)		1.441 (0.566–3.667)
LEP rs7799039	AA	53 (15)	1.00	0.318	1.00	0.274
	AG + GG	298 (85)	0.652 (0.282–1.508)		0.712 (0.388–1.307)
LEPR rs1137101	GG	73 (21)	1.00	0.974	1.00	0.945
	AG + AA	278 (79)	0.989 (0.514–1.902)		1.019 (0.596–1.742)
5–HT2C rs3813929	TT/CT	87 (25)	1.00	0.001	1.00	0.556
	CC	264 (75)	0.251 (0.109–0.578)		1.164 (0.702–1.928)
UCP2 rs659366	TT	49 (14)	1.00	0.505	1.00	0.884
	CT + CC	302 (86)	1.330 (0.574–3.082)		1.056 (0.511–2.181)
UCP2 rs660339	AA	49 (14)	1.00	0.238	1.00	0.675
	AG + GG	302 (86)	0.568 (0.222–1.452)		1.167 (0.567–2.405)
UCP3 rs1800849	CC	54 (15)	1.00	0.019	1.00	0.128
	CT + TT	297 (85)	0.305 (0.113–0.821)		0.624 (0.341–1.144)
SH2B1 rs7498665	GG	223 (64)	1.00	0.594	1.00	0.946
	AG + AA	294 (84)	0.815 (0.385–1.726)		0.980 (0.544–1.765)
TAS1R2 rs35874116	CC + CT	184 (52)	1.00	0.790	1.00	0.933
	TT	167 (48)	1.706 (0.626–1.850)		1.019 (0.658–1.579)
TAS1R2 rs9701796	GG + CG	117 (33)	1.00	0.353	1.00	0.341
	CC	234 (67)	0.761 (0.428–1.354)		1.252 (0.788–1.989)
FTO rs9939609	AA	71 (20)	1.00	0.911	1.00	0.058
	AT + TT	280 (80)	0.963 (0.492–1.882)		0.595 (0.348–1.017)

n = 351. Variables with adjustments for age, skin color, preoperative BMI, previous pregnancy and age at onset of obesity.