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. 2022 Dec 16;50(6):1629–1635. doi: 10.1007/s00259-022-06081-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Increased [⁶⁸Ga]Ga-FAPI-04 uptake corresponds to the accumulation of FAP⁺-expressing myofibroblasts in myocardial biopsy. Representative image of a [⁶⁸Ga]Ga-FAPI-04-PET-CT scan and the corresponding image of cardiac MRI with late gadolinium enhancement (LGE) and T1-mapping of a patient with myocardial fibrosis (MF) in the upper part of the image. Myocardial biopsy was performed from a [⁶⁸Ga]Ga-FAPI-04 positive- and LGE-positive region. Representative pictures of sirius red staining and immunofluorescence staining with the fibroblast marker prolyl-hydroxylase-4β (P4Hβ), the myofibroblast marker α-smooth-muscle actin (αSMA), and fibroblast activation protein (FAP) and Voronoi tessellations are shown in the lower part of the figure. Myocardial tissue sections of two healthy donor hearts of heart-transplanted patients were analyzed as controls. SAX: short axis view, LAX: long axis view