Fig. 5.

Astrocyte–neuron signaling is not altered by neuronal α-synuclein. a Representative Ca²⁺ fluorescence traces obtained from TgNg and iSyn mice (left), heat maps indicating Ca²⁺ levels from TgNg and iSyn mice (middle), raster plots indicating Ca²⁺ events from TgNg and iSyn mice (right). b Ca²⁺ events per minute obtained from TgNg and iSyn mice. c Representative SIC (shaded in blue) and mEPSC traces obtained from TgNg and iSyn mice. d SICs per minute obtained from TgNg and iSyn mice (left), cumulative SIC frequency obtained from TgNg and iSyn mice (right; the maximum difference between the cumulative distributions, D, is 0.074561 with a corresponding p > 0.1). e mEPSC amplitude (left) and cumulative amplitude (right; the maximum difference between the cumulative distributions, D, is 0.22012 with a corresponding p < 0.001) obtained from TgNg and iSyn mice. f mEPSC frequency (left) and cumulative frequency (right; the maximum difference between the cumulative distributions, D, is 0.58571 with a corresponding p < 0.025) obtained from TgNg and iSyn mice. Data are expressed as mean ± s.e.m. (*) p < 0.05 and (**) p < 0.01