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. 2023 Apr 20;14:2266. doi: 10.1038/s41467-023-37872-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–e Transmission electron microscope (TEM) (a) and energy dispersive spectroscopy (EDS) elemental mapping images (b) of rough SiO₂ nanoparticles are shown. c Nitrogen adsorption-desorption isotherm of rough SiO₂ nanoparticles along with Barrett-Joyner-Halenda (BJH) pore size distribution plot is shown. Biological triplicates were performed independently. TPZ loading content in SiO₂ nanoparticles (d) and glutathione (GSH)-responsive TPZ release (e) were measured at the indicated time. n = 3 biologically independent samples. One-way analysis of variance (ANOVA) for (e). Fluorescence images (f) and flow cytometry analysis (g) of neutrophils loaded with smooth and rough SiO₂-TPZ. Biological triplicates were performed independently. h Cellular SiO₂ content in hPSC-derived CAR-neutrophils was measured. n = 5 biologically independent samples, two-tailed Student’s t test. Cellular viability (i), n = 3 biologically independent samples, transmigration (j), n = 5 biologically independent samples, chemoattraction abilities (k, l), n = 20 biologically independent samples, and ROS generation ability (m) of hPSC-derived CAR-neutrophils loaded with or without rough SiO₂-TPZ were shown, n = 5 biologically independent samples, two-tailed Student’s t test. PMA: phorbol myristate acetate. All data in this figure are represented as mean ± SD. Source data are provided as a Source Data file.