Table 3.
Associations of biological ages at baseline with incident depression/anxiety disorders at follow-up (fully adjusted model)a
| Biological age | Incident depression/anxiety disorders | Incident depression | Incident anxiety | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Ncase/Ntotal | Hazard ratio (95% CI) | p-value | Ncase/Ntotal | Hazard ratio (95% CI) | p-value | Ncase/Ntotal | Hazard ratio (95% CI) | p-value | |
| KDM-BA acceleration (Continuous) | 16523/369745 | 1.059 (1.033 – 1.085) | <0.0001 | 11042/369745 | 1.070 (1.039 – 1.103) | <0.0001 | 8472/369745 | 1.038 (1.002 – 1.075) | 0.037 |
| KDM-BA acceleration (Quartiles) | |||||||||
| Q1 | 2858/92436 | Ref | 1924/92436 | Ref | 1442/92436 | Ref | |||
| Q2 | 3952/92436 | 1.103 (1.035 – 1.175) | 0.0024 | 2653/92436 | 1.077 (0.997 – 1.163) | 0.06 | 2012/92436 | 1.056 (0.961 – 1.159) | 0.26 |
| Q3 | 4696/92437 | 1.105 (1.048 – 1.166) | 0.0002 | 3005/92437 | 1.113 (1.043 – 1.187) | 0.0012 | 2538/92437 | 1.107 (1.013 – 1.211) | 0.025 |
| Q4 | 5017/92436 | 1.125 (1.053 – 1.201) | 0.0005 | 3460/92436 | 1.161 (1.073 – 1.257) | 0.0002 | 2480/92436 | 1.083 (1.004 – 1.169) | 0.039 |
| PhenoAge acceleration (Continuous) | 16523/369745 | 1.113 (1.096 – 1.130) | <0.0001 | 11042/369745 | 1.145 (1.125 – 1.167) | <0.0001 | 8472/369745 | 1.063 (1.040 – 1.087) | <0.0001 |
| PhenoAge acceleration (Quartiles) | |||||||||
| Q1 | 3726/92436 | Ref | 2289/92436 | Ref | 2095/92436 | Ref | |||
| Q2 | 3753/92436 | 1.032 (0.985 – 1.080) | 0.18 | 2445/92436 | 1.075 (1.015 – 1.139) | 0.014 | 2021/92436 | 1.012 (0.951 – 1.076) | 0.71 |
| Q3 | 4152/92437 | 1.132 (1.082 – 1.185) | <0.0001 | 2823/92437 | 1.209 (1.143 – 1.280) | <0.0001 | 2085/92437 | 1.058 (0.994 – 1.127) | 0.07 |
| Q4 | 4892/92436 | 1.286 (1.228 – 1.346) | <0.0001 | 3485/92436 | 1.405 (1.328 – 1.487) | <0.0001 | 2271/92436 | 1.151 (1.079 – 1.226) | <0.0001 |
aAnalyses were conducted in 369,745 participants free of depression/anxiety at baseline; Model adjusted for age, sex, ethnic, BMI, smoking status, healthy alcohol intake, healthy physical activity, hypertension, diabetes, coronary heart disease, and Townsend deprivation index. The examination center was controlled for as a random effect. Two-sided statistical tests were conducted and no adjustments were made for multiple comparisons. Bolded p-values are statistically significant (<0.05).