Table 4.
Associations of biological ages at baseline with co-incident depression and anxiety at follow-upa
| Biological ages | Co-incident depression and anxiety | ||
|---|---|---|---|
| Ncase/Ntotal | Hazard ratio (95% CI) | p-value | |
| KDM-BA acceleration (Continuous) | 2991/369745 | 1.038 (0.979 – 1.101) | 0.21 |
| KDM-BA acceleration (Quartiles) | |||
| Q1 | 508/92436 | Ref | |
| Q2 | 713/92436 | 1.019 (0.877 – 1.185) | 0.80 |
| Q3 | 847/92437 | 1.043 (0.892 – 1.220) | 0.60 |
| Q4 | 923/92436 | 1.064 (0.938 – 1.207) | 0.34 |
| PhenoAge acceleration (Continuous) | 2991/369745 | 1.093 (1.054 – 1.132) | <0.0001 |
| PhenoAge acceleration (Quartiles) | |||
| Q1 | 658/92436 | Ref | |
| Q2 | 713/92436 | 1.107 (0.995 – 1.231) | 0.06 |
| Q3 | 756/92437 | 1.159 (1.042 – 1.289) | 0.0066 |
| Q4 | 864/92436 | 1.282 (1.152 – 1.427) | <0.0001 |
aAnalyses were conducted in 369,745 participants free of depression/anxiety at baseline; the Model was adjusted for age, sex, ethnic, BMI, smoking status, healthy alcohol intake, healthy physical activity, hypertension, diabetes, coronary heart disease, and Townsend deprivation index. The examination center was controlled for a random effect. Two-sided statistical tests were conducted and no adjustments were made for multiple comparisons. Bolded p-values are statistically significant (<0.05).