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. 2023 Apr 20;14:2131. doi: 10.1038/s41467-023-37838-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Volcano plots of differential ribosome occupancy for Pro and Ala codons in the heart of Rpl3l^−/− mice compared with that of control mice (n = 4 mice). P values were calculated by two-sided Student’s t test and adjusted by Benjamini-Hochberg method for multiple comparisons, and the gray dashed lines indicate an adjusted P value of 0.05. b Metagene plots for the regions surrounding Pro/Ala sites with altered elongation dynamics for footprints of Ribo-seq analysis performed with the heart of Rpl3l^+/+ or Rpl3l^−/− mice (n = 4 mice). The average of replicates is shown. c GO analysis of genes with significantly altered elongation dynamics at Pro or Ala codons. P values were calculated as EASE scores, modified Fisher’s exact P values. The 10 GO terms with the smallest P values are listed. d Distribution of ribosome footprint occupancy at the A-site along the coding regions of Myl4 and Atp5o mRNAs in the heart of Rpl3l^+/+ and Rpl3l^−/− mice (n = 4 mice). The average of four replicates is shown. RPM, reads per million reads. e Cumulative fraction for fold change in protein expression in the heart of Rpl3l^−/− mice compared with that of control mice (n = 4 mice). The expression level of proteins was analyzed by DIA-based MS, and the results are shown for all proteins (n = 3376) and for those encoded by the genes with differential ribosome occupancy at Pro or Ala codons. The P value was calculated by the two-tailed Mann-Whitney U test. Source data are provided as a Source Data file.