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. 2023 Apr 20;14:2131. doi: 10.1038/s41467-023-37838-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, b Venn diagrams for the number of disome peaks in the heart of Rpl3l^+/+ or Rpl3l^−/− mice (n = 4 mice) (a) as well as for the number of Pro/Ala codons with significantly increased ribosome occupancy at the A-site in the heart of Rpl3l^−/− mice compared with that of control mice (b). c Histogram for fold change in disome peak intensity in the heart of Rpl3l^−/− mice compared with that of control mice (n = 4 mice). The black dotted line corresponds to a fold change of 1. d GO analysis of genes with disome peaks in the heart of Rpl3l^+/+ or Rpl3l^−/− mice. P values were calculated as EASE scores, modified Fisher’s exact P values. The 10 GO terms with the smallest P values are listed. e Cumulative fraction for the fold change in protein expression in the heart of Rpl3l^−/− mice compared with that of control mice (n = 4 mice). The expression level of proteins was analyzed by DIA-based MS, and the results are shown for all proteins (n = 3376) and for those with disome peaks (n = 156) in a. The P value was calculated with the two-tailed Mann-Whitney U test. Source data are provided as a Source Data file.