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. 2023 Apr 20;6:435. doi: 10.1038/s42003-023-04819-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Columns show specific TAD boundaries (B1–8) deleted in this study, key developmental genes within the flanking TADs (Gene_i-1 and Gene_i+1), approximate boundary deletion sizes (Deletion_i), and the number of putative CTCF clusters deleted. All data in subsequent columns are summaries of phenotypic information for mice homozygous for the respective TAD boundary deletions. These include effects on viability (fully lethal in red cross mark, subviable shown in red or yellow arrow to indicate magnitude of effect, no deviation from expected Mendelian ratios shown in green check marks), fertility of both male and female homozygous animals (at least three homozygous males and three homozygous females were assessed for reproductive fitness, green check marks indicate fertile animals), and overt physiological phenotypes observed. Column for chromatin change indicates presence of significant DI changes and/or significant alterations to intra-domain chromatin contact frequencies in the flanking TADs, assessed by Hi-C. The last column indicates whether significant expression changes were observed for genes in the vicinity of the deleted TAD boundary. n.a. not applicable, n.d. not determined.