Fig. 4. Single-cell RNA-seq analyses indicate that the nine IBD genes identified in this study are expressed in ileum from Crohn’s disease cases.

A UMAP plot of clustered scRNA-seq cells from ileal CD inflamed and uninflamed samples which can be annotated broadly into 31 cell types. B scRNA-seq average expression of the 11 genes identified from pathway analyses across the 31 cell types. For each gene, the non-zero expressed cells were utilized to calculate the average expression in each cell type. The average expression levels in all cell types were scaled for comparison.