Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 30;145(5):541–559. doi: 10.1007/s00401-023-02562-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Detection of pathological ɑSyn in the urinary bladder of MSA patients and controls. Immunohistochemical analysis of endogenous ɑSyn in human urinary bladder shows ɑSyn expression in a βIII tubulin-positive intramural ganglia and b neuronal synapses (white arrows). For the detection of pathological ɑSyn urinary bladder tissue was treated with proteinase K (PK) and stained for PSer129- ɑSyn. c PK-resistant PSer129-ɑSyn is detected in urinary bladder tissue of both controls and MSA patients. A granular pattern of PK-resistant PSer129-ɑSyn is observed throughout the detrusor and lamina propria in addition to a vascular pattern where ɑSyn deposits around the vascular epithelium (black arrows) (scale bar represents 2 mm for overview figures and 50 µm for the detailed panels). The PSer129-⍺Syn immunostaining is localized to the perivascular area in the control subject whereas it extends more deeply into perivascular space for the MSA case. d Semi-quantitative analysis of PK-resistant PSer129-ɑSyn pathology in controls and cases shows significantly more vascular pathology for MSA cases (n = 8, *p = 0.02 with a non-parametric Mann–Whitney unpaired two-tailed t test) but e no differences in the granular PSer129-ɑSyn is detected (n = 8, p > 0.05 with a non-parametric Mann–Whitney unpaired two-tailed t test)