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. 2023 Apr 20;14:2273. doi: 10.1038/s41467-023-37705-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Sequence alignment of TANGO1’s cargo-recognition domain from Homo sapiens and Drosophila melanogaster computed with ClustalOmega. Conserved and semi-conserved residues are displayed by asterisks and colons also highlighted in orange and purple, respectively. Disulfide bridges are indicated by orange lines, secondary structure elements above and below, according to the determined structure or the chemical shift index (CSI). The missing second disulfide bridge in invertebrates is indicated by dotted red line (See also Supplementary Fig. 3). b Multiple sequence alignment of several invertebrate organisms. c ¹⁵N{¹H} hetNOE of TANGO1’s cargo-recognition domain from Homo sapiens and Drosophila melanogaster. Data are presented as mean values +/− standard deviation calculated from all measurements (n = 3). Source data are provided as a Source Data file. d Regions that display motions on the pico- to nanosecond timescale projected to the structures of the domains from human and a predicted structure of D. melanogaster (AF-Q9VMA7-F1 [https://alphafold.ebi.ac.uk/entry/Q9VMA7], accessed via https://alphafold.ebi.ac.uk/) in red. Disulfide bridges are shown as yellow sticks.