Table 1.
Baseline characteristics of the cohort by treatment modality in the trichotomized PC-CS subgroup
| Variables | PC-CS 0–3 | PC-CS 4–5 | PC-CS 6–10 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMT (n = 46) | EVT (n = 188) | P value | SMT (n = 68) | EVT (n = 249) | P value | SMT (n = 68) | EVT (n = 209) | P value | |
| Age, years, median (IQR) | 73 (65–77) | 63 (57–71) | < 0.001 | 67 (59–76) | 66 (56–74) | 0.230 | 65 (56–73) | 64 (55–73) | 0.640 |
| Female, n (%) | 15 (32.6) | 38 (20.2) | 0.072 | 23 (33.8) | 62 (24.9) | 0.141 | 15 (22.1) | 64 (30.6) | 0.174 |
| Baseline NIHSS, median (IQR) | 30 (16–35) | 31 (23–34) | 0.301 | 29 (17–33) | 27 (18–34) | 0.952 | 23 (10–32) | 20 (14–30) | 0.729 |
| Medical history, n (%) | |||||||||
| Ischemic stroke | 17 (37.0) | 43 (22.9) | 0.05 | 15 (22.1) | 56 (22.5) | 0.94 | 16 (23.5) | 41 (19.6) | 0.488 |
| Hypertension | 35 (76.1) | 138 (73.4) | 0.710 | 47 (69.1) | 170 (68.3) | 0.894 | 52 (76.5) | 142 (67.9) | 0.182 |
| Hyperlipidemia | 16 (34.8) | 67 (35.6) | 0.913 | 24 (35.3) | 65 (26.1) | 0.135 | 29 (42.6) | 82 (39.2) | 0.618 |
| Diabetes mellitus | 9 (19.6) | 50 (26.6) | 0.325 | 19 (27.9) | 51 (20.5) | 0.189 | 12 (17.6) | 48 (23) | 0.355 |
| Coronary heart disease | 11 (23.9) | 29 (15.4) | 0.17 | 11 (16.2) | 53 (21.3) | 0.352 | 5 (7.4) | 23 (11.0) | 0.386 |
| Atrial fibrillation | 4 (8.7) | 20 (10.6) | 1.00* | 10 (14.7) | 73 (29.3) | 0.015 | 10 (14.7) | 43 (20.6) | 0.285 |
| IVT, n (%) | 9 (19.6) | 38 (20.2) | 0.922 | 24 (35.3) | 50 (20.1) | 0.009 | 14 (20.6) | 31 (14.8) | 0.264 |
| Occlusion site, n (%) | 0.004 | 0.129 | < 0.001 | ||||||
| Distal BA | 10 (21.7) | 30 (16) | 24 (35.3) | 116 (46.6) | 11 (16.2) | 76 (36.4) | |||
| Middle BA | 20 (43.5) | 40 (21.3) | 31 (45.6) | 76 (30.5) | 49 (72.1) | 79 (37.8) | |||
| Proximal BA | 6 (13) | 55 (29.3) | 5 (7.4) | 26 (10.4) | 3 (4.4) | 25 (12) | |||
| VA–V4 | 10 (21.7) | 63 (33.5) | 8 (11.8) | 31 (12.4) | 5 (7.4) | 29 (13.9) | |||
| Time metrics, min, median (IQR) | |||||||||
| Onset-puncture time | 449 (149–591) | 315 (203–537) | 0.575 | 300 (228–674) | 320 (218–490) | 0.451 | 425 (261–803) | 345 (240–472) | 0.392 |
| Onset-imaging time | 179 (71–400) | 196 (81–386) | 0.764 | 195 (103–304) | 211 (91–357) | 0.676 | 217 (74–401) | 219 (88–329) | 0.799 |
| Puncture-recanalization time | NA | 107 (77–151) | NA | NA | 101 (65–151) | NA | NA | 107 (70–154) | NA |
| Door-needle time | 96 (40–108) | 7 2(47–110) | 0.564 | 60 (47–87) | 78 (50–97) | 0.309 | 56 (47–108) | 58 (45–109) | 0.953 |
| mTICI 2b/3, n (%) | NA | 142 (75.5) | NA | NA | 204 (81.9) | NA | NA | 175 (83.7) | NA |
The missing door-needle time data were 2 (22%), 3 (12.5%), and 2 (14.3%) in the SMT and 11 (28.9%), 10 (20%), and 11 (35.5%) in the EVT of the trichotomized PC-CS subgroup. There was one missing data point with OPT and puncture-recanalization time in each EVT group of the trichotomized PC-CS subgroup
BA basilar artery, EVT endovascular treatment plus standard medical therapy, IQR interquartile range, mRS modified Rankin Scale, mTICI Modified Thrombolysis in Cerebral Infarction score, NIHSS National Institutes of Health Stroke Scale, PC-CS posterior circulation collateral score, SMT standard medical therapy, VA-V4 V4 of vertebral artery, IVT intravenous thrombolysis, NA not applicable
*Fisher exact test