Fig. 3.

E-MET enhances L-MET preventing the loss of spontaneous locomotor activity in 12-month-old Epm2a^−/− and shows similar effect than L-MET in 12-month-old Epm2b^−/− mice. We studied the benefits of E-MET in the appearance of spontaneous movement deterioration in 12-month-old mice. We evaluated the accumulated movement (a, b), the stereotyped movement (c, d), and the rearing movement (e, f) of both models. Data are shown as a mean ± SEM. A one-way ANOVA test was performed with a Turkey’s multiple comparisons test between experimental groups. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Statistical differences between groups in figures c and d are shown as * for Epm2a^−/− vs Epm2a^−/− + E-MET or Epm2b^−/− vs Epm2b^−/− + E-MET; # for Epm2a^−/− vs Epm2a^−/− + L-MET or Epm2b^−/− vs Epm2b^−/− + L-MET; + for Epm2a^−/− + E-MET vs Epm2a^−/− + L-MET or Epm2b^−/− + E-MET vs Epm2b^−/− + L-MET