Fig. 2.

Delayed diagnosis for patients with multi-organ autoimmunity/autoinflammation. A Histogram of diagnostic delay. B Frequency polygon for age at diagnosis and age at onset in years, 3 years grouped for plotting. C Age at onset and diagnostic delay for the calendar year of symptom onset. It is difficult to estimate calendar time effects with our cohort. Patients with symptom onset several decades ago and in later age are underrepresented in the cohort, due to the prospective inclusion of mostly living patients in the registry. D Male patients experience symptom onset earlier than females. Wilcoxon rank sum test p = 0.024, n = 352