Table 2.

Candidate genes known to cause multi-organ autoimmunity or autoinflammation

Gene abbreviation	Gene name
AIRE	Autoimmune regulator
ADA2	Adenosine deaminase 2
BACH2	BTB domain and CNC homolog 2
CD25/IL2-RA	Interleukin 2 receptor subunit alpha
CTLA4	Cytotoxic T-lymphocyte associated protein 4
FOXP3	Forkhead box P3
ICOS	Inducible T cell costimulator
LAT	Linker for activation of T cells
LRBA	LPS responsive beige-like anchor protein
NFKB1	Nuclear factor kappa B subunit 1
NFKB2	Nuclear factor kappa B subunit 2
PIK3CD	Phosphoinositide 3 kinase catalytic subunit delta
PIK3R1	Phosphoinositide 3 kinase regulatory subunit 1
PRKCD	Protein kinase C delta
RELA	Nuclear factor kappa B subunit 3
SOCS1	Suppressor of cytokine signaling 1
STAT1-GOF	Signal transducer and activator of transcription 1
STAT3-GOF	Signal transducer and activator of transcription 3
TNFRSF13B	Tumor necrosis factor receptor superfamily member 13B
TPP2	Tripeptidyl peptidase 2

GOF, gain-of-function