Table 4.

Characteristics of patients in the GAIN registry

Characteristics	Total (n = 419)	No.	%
Gender	Male	201	48.0%
	Female	217	51.8%
	Missing	1	0.2%
Agea	Mean age (SD), 40 (±19)
	0 – 9	25	6.0%
	10 – 19	49	11.7%
	20 – 29	67	16.0%
	30 – 39	69	16.5%
	40 – 49	61	14.6%
	50 –59	84	20.0%
	60 – 69	41	9.8%
	70 – 79	17	4.1%
	80+	6	1.4%
Status	Alive	399	95.2%
	Deceased	14	3.3%
	Discharged	1	0.2%
	Lost to follow-up	5	1.2%
Mutated geneb	NFKB1	48	11.5%
	CTLA4	40	9.5%
	TNFRSF13B	39	9.3%
	NFKB2	18	4.3%
	LRBA	13	3.1%
	STAT3 GOF	12	2.9%
	ADA2	10	2.4%
	STAT1	9	2.1%
	STAT3	9	2.1%
	IKZF1	7	1.7%
	PIK3CD	7	1.7%
	ICOS	6	1.4%
	FAS	5	1.2%
	UNC13D	3	0.7%
	BACH2	2	0.5%
	CARMIL2	2	0.5%
	FLG	2	0.5%
	MST1	2	0.5%
	SH2D1A	2	0.5%
	Other	22	5.3%
	Not tested	43	10.3%
	No mutation found	87	20.8%
	No information availablec	41	9.8%

^aIn case of death, lost to follow-up, and discharge, age at death or last information was used

^bSeveral mutated genes per patient are possible. Therefore, percentages do not sum up to 100%

^cPending result, or no information