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. 2023 Apr 21;21:273. doi: 10.1186/s12967-023-04110-w

Table 1.

Baseline characteristics of tumor, stratified by patient, treatment and response post-COVID-19 infection/vaccine

Case n° Pathology Patient age (years)/Sex Treatment Covid-19/ Vaccine Follow-up References
1 Classical hodgkin lymphoma 61/Male No corticosteroid or immune-chemo-therapy was administered. Covid-19 Four months after COVID-19 diagnosis: complete remission [11]
2 Acute myeloid leukemia 57/Female NO chemotherapy for AML. COVID-19 was treated with remdesivir at 200 mg intravenously (IV) on the first day, followed by 100 mg daily for 5 days and dexamethasone IV at 8 mg daily for 10 days. Trasfusion with six units of packed red blood cells and ten  units of platelets. Pirfenidone, colchicine (0.6 mg twice daily), and oxygen therapy Covid-19 Six months after, diagnosis of COVID-19complete remission after 8 months later relapse [12]
3 Acute myeloid leukemia 63/Female Postpone treatment protocol. Supportive therapy only (Fluconazole 150 mg 3 times daily/Azithromycin 500 mg daily and Prednisone 100 mg for 5 days) Covid-19 After 5 weeks from COVID-19 diagnosis remission and one year later no evidence of disease [13]
4 T-ALL 28/Male COVID-19 supportive treatment (Azithromycin 500 mg/day and Prednisone 40 mg daily for 5 days) Covid-19 After 6 weeks diagnosis of COVID-19: no evidence of disease [13]
5 Advanced follicular lymphoma 79/Female Without lymphoma treatment Covid-19 Nine months later diagnosis of COVID-19: complete remission [14]
6 Follicular lymphoma 61/Male NA Covid-19 After 5 months from diagnosis of COVID-19: complete remission [15]
7 Relapsed/refractory NK/T-cell lymphoma associated with Epstein-Barr virus (EBV) and autoimmune hemolytic anemia (AIHA) 20/Male Red-blood cell transfusions and methylprednisolone at rate of 1 mg/kg of body weight per day were administered. No antiviral or cloroquine drugs were administered Covid-19 Transient remission of NK lymphoma: remission during COVID-19 infection, followed after 1 month : lymphoma relapse. [16]
8 Multiple myeloma 76/Female A single dose of filgrastim, levofloxacin and acyclovir were administered. After the decreasing blood-oxygen levels, the patient was treated with dexamethasone and remdesivir. Covid-19 During the next 2 months from COVID-19 diagnosis: no evidence of multiple myeloma [17]
9 Chronic lymphocytic leukaemia (CLL) 67/Male Asymptomatic untreated CLL. Multiple treatments including intravenous immunoglobulin and broad-spectrum antibiotics were used for febrile neutropenia Covid-19 Complete remission after 12 months of follow-up after diagnosis of COVID-19 [18]
10 Metastatic renal cell carcinoma cancer (mCRC) 71/Male Aside from supportive measures, no specific treatment for COVID-19 was administered. Covid-19 Follow-up on 6 months from COVID-19 diagnosis: partial regression of metastatic lesions [19]
11 Metastatic renal cell carcinoma cancer (mCRC) 58/Male Antibiotics; firstly, clarithromycin and, subsequently, amoxycillin clavulanate for persistent fever. No antineoplastic treatment. Covid-19 Four months later COVID-19 diagnosis: reduction in lung metastases [19]
12 Metastatic colorectal cancer (mCRC) 65/Male FU/FA/BEVA /depotentiated treatment, with the last cycle performed 1 month before COVID-19 infection Covid-19 Follow-up at 18 months: from COVID-19 diagnosis complete response with regression of hepatic lesions [20/21]
13 Metastatic colorectal cancer (mCRC) 58/Male The patient refused post-operative chemotherapy. Covid-19 Post COVID-19 infection: reduction of the liver metastatic lesion. Time to-Progression: 23 months [20/21]
14 Metastatic colorectal cancer (mCRC) 60/Female After six cycles with FOLFIRI/PANI, CT scan in September 2020 displayed disease stabilization Covid-19 Progression of disease at 2 months from diagnosis of COVID-19 [21]
15 Primary cutaneous anaplastic large-cell lymphoma 57/Male NA COVID-19 vaccination (BionTech/Pfizer) 1 week before the second dose of COVID-19 vaccination: complete resolution of untreated lymphoma [22]
16 Myoepithelial carcinoma of the left parotid and lung lesion 61/Female Close surveillance. Covid19 vaccination (mRNA-1273) Persistent tumor shrinkage on follow-up of 9 months, after the second dose of the vaccine. [23]