Fig. 3.

WGCNA analysis of lipidomics data. (A) Each ME consisted of a subclass of lipids. Correlations between MEs and HEs severity in DR, NPDR and PDR were calculated. Levels of lipids in ME1 (red frame) showed positive correlations with HEs severity in DR, NPDR and PDR. (B) Pie chart of lipid composition in ME1. (C) Heat map of correlation between TGs carbon chain length and unsaturation with HEs severity in ME1. * indicated a P value < 0.01, and ** indicated a P value < 0.0001 for Pearson correlation. Abbreviations: HEs, hard exudates; ME, module; TGs, triglycerides; WGCNA, weighted gene co-expression network analyses.