Table 4.

Risk Stratification of TMA into Standard-Risk and High-Risk

Standard-Risk TMA	High-Risk TMA
Peak LDH <2 times ULN	Peak LDH >2 times ULN*
Spot rUPCR <1 mg/mg	Spot rUPCR ≥1 mg/mg
KDIGO stage I AKI	Any organ dysfunction developing in the setting of TMA except KDIGO stage I AKI (see Table 5)
Normal sC5b-9	Elevated sC5b-9 (>ULN)
	Concurrent acute GVHD grade II-IV*
	Concurrent systemic infection (bacterial or viral)*

KDIGO indicates Kidney Disease Improving Global Outcomes.

International Consensus Risk stratification is a modification of Jodele et al.¹, with additional risk factors indicated by an asterisk.