Table 5.
Definitions of Multiorgan Dysfunction in TA-TMA
| Organ | Manifestations |
|---|---|
| Renal | ≥50% reduction in GFR from pre-HCT conditioning value calculated by serum creatinine or cystatin-C or increase in serum creatinine ≥2 times baseline |
| Pulmonary | Any need for positive-pressure ventilation (noninvasive or invasive) for ≥24 hours in the absence of definite etiology (i.e., adenovirus pneumonia, fluid overload, or severe sepsis), diffuse alveolar hemorrhage |
| Cardiovascular | Pulmonary hypertension diagnosed by a cardiologist using cardiac catheterization, or pulmonary hypertension diagnostic criteria on echocardiography |
| Serositis | Clinically significant serositis (pleural or pericardial effusions or ascites) requiring medical therapy (ie, diuretics) or drainage in the absence of other causes (eg, VOD/SOS, congestive heart failure) |
| Central nervous system | Confusion, altered mental status, seizures with or without imaging evidence of posterior reversible encephalopathy syndrome (PRES) |
| GI | GI bleeding and/or intestinal strictures requiring medical or surgical interventions |