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Antidepressant-like effect of 16 after chronic administration in the rat forced swim test. Both vortioxetine and 16 were administered intraperitoneally for 14 consecutive days. Sixty minutes after the last injection the test was performed. Vehicle-treated groups received 10% cyclodextrin for 14 days. Statistical analysis: one-way ANOVA followed by Newman-Keuls post hoc or Student t test: *p < 0.05 vs vehicle-treated group; n = 10 per group.
