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. 2023 Apr 4;14(8):1474–1489. doi: 10.1021/acschemneuro.3c00033

Table 2. Selected in Vitro Assays for 16 and the Reference Molecules.

compound solubility (pH = 7.4, mg/mL)a PAMPA permeability (10–6 cm/s)b rat liver microsomes t0,5 [min]c rat liver microsomes Clint ((μL/min)/mg)c
16 >2 6.24 >60 <115.5
perphenazine 0.0306      
sulpiride   0.016    
propranolol     >60 <115.5
a

Thermodynamic solubility measured at rt.

b

Compounds tested at 10–5 M using the PAMPA Plate System Gentest.

c

Molecule assayed at 10–7 M. Empty cells: not examined.