Table 3. Stability Assays for 16 (Chemical Stability in PBS, Plasma, and Brain Homogenate).

time point [min]	% compound remaining, rta	% compound remaining (rat plasma, 37 °C)	% compound remaining (brain homogenate)b
0	100 ± 0.2	100 ± 0.1	100 ± 0.3
15	98.43 ± 1.8	97.21 ± 0.8	97.81 ± 2.1
30	94.23 ± 1.8	90.35 ± 1.4	92.56 ± 1.9
60	92.46 ± 2.2	79.65 ± 2.5	87.12 ± 3.2
120	86.63 ± 2.3	45.37 ± 2.2	49.73 ± 2.4
240	62.21 ± 1.7	21.46 ± 1.2	25.34 ± 1.6

^aAssay performed in PBS, rt.

^bCompound 16 was incubated with brain homogenate suspended in Tris-HCl buffer.