Table 4. Open Field Test in Rats Showing the Influence of Acute and Subchronic 16 and Vortioxetine Administration on the Locomotor Activity.
| treatment | dose | total distance traveled | rearing | X ambulation | Y ambulation | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Acute Treatmenta | |||||||||||||
| vehicle | 485.3 | ± | 43.0 | 29.0 | ± | 2.0 | 187.5 | ± | 22.0 | 190.2 | ± | 18.7 | |
| 16 | 3 | 506.3 | ± | 36.7 | 34.5 | ± | 5.4 | 221.3 | ± | 17.9 | 213.7 | ± | 18.5 |
| Chronic Treatmentb | |||||||||||||
| vehicle | 2467 | ± | 142 | 53.8 | ± | 3.4 | 246.4 | ± | 14.7 | 243.1 | ± | 18.8 | |
| 16 | 3 | 2575 | ± | 92 | 52.2 | ± | 2.9 | 260.4 | ± | 15.0 | 255.3 | ± | 12.3 |
| vortioxetine | 8 | 2753 | ± | 120 | 50.6 | ± | 5.4 | 260.1 | ± | 10.4 | 265.9 | ± | 10.4 |
a
The compounds were administered ip 30 min prior the experiments. Vehicle-treated groups: 10% cyclodextrin (ip). Statistical analysis: one-way ANOVA followed by Newman–Keuls post hoc or Student t test. n = 6 per group.
b
Both vortioxetine and 16 were administered intraperitoneally for 14 consecutive days. Sixty minutes after the last injection, the test was performed. Vehicle-treated groups received 10% cyclodextrin for 14 days. Statistical analysis: one-way ANOVA followed by Newman–Keuls post hoc or Student t test. n = 10 per group.