Figure 5.

Evaluation of aptamer binding ex vivo

(A) Fluorescent imaging of brain tissues from different patients with astrocytoma; MRI of patient brains with gliomas (1, 5, 9); light microscopy of corresponding resected tumor tissues (2, 6, 10); fluorescence microscopy of the tumor tissues stained with Gli-233BV and Gli-55BV (3, 7, 11×), 40× magnified areas of the stained tumor tissues (4, 8, 12). (B) Light (2, 5) and fluorescence microscopy of brain meningioma tissues from different patients stained with Gli-233BV and Gli-55BV (3, 6×), 40× magnified areas of the stained meningioma tissues (4, 7). (С) Light (C1, C4) and fluorescent (C2, C5) imaging of relatively healthy brain tissues from the peritumoral region, 40× magnified areas of the stained meningioma tissues (3, 6). Magnification 1.5–6×, 40×. Scale bars, 20 mm, 10 mm, 7 mm, 5 mm, 50 µm.