Table 1.
Clinical characteristics of patients with astrocytoma and the number of CTCs detected in the blood
| Patient/gender/age/surgery no. | Histologic type, grade | Tumor location | Therapy | No. of CTCs before the surgery/in remission/at relapse | PFS after first/second tumor resection (months) | Overall survival time after diagnosis (months) | Quality of life, before the surgery/in remission period (Karnofsky scale, %) |
|---|---|---|---|---|---|---|---|
| Patient 1/female/67/2 | astrocytoma, grade II (relapse) | the left temporal lobe of the brain | tumor resection (2 times), chemo- and radiotherapy | 43 | 6 | 16 | 80/90 |
| Patient 2/female/43/2 | astrocytoma, grade II (relapse) | the left parietal, occipital lobe of the brain, posterior parts of the left lateral ventricle | tumor resection (3 times), chemo- and radiotherapy | 18/1/3 | 12/5 | 23.5 | 80/90 60/60 |
| Patient 3/male/38/2 | astrocytoma, grade II (relapse) | the left temporal lobe, the lower horn of the left lateral ventricle | tumor resection (2 times), chemo- and radiotherapy | 49/10/27 | 5.5 | 15 | 80/80 20/30 |
| Patient 7/female/68/1 | astrocytoma, grade II (relapse) | the left occipital and parietal lobe of the brain’s left lateral ventricle | tumor resection (2 times), chemo- and radiotherapy | 38 | 17 | 25 | 80/80 |
| Patient 12/female/78/1 | astrocytoma, grade II | the left temporal lobe of the brain | tumor resection, chemo- and radiotherapy | 12 | 11 | 15 | 70/80 |
| Patient 14/female/59/1 | astrocytoma, grade II | the left temporal lobe of the brain | tumor resection, chemo- and radiotherapy | 7 | 15 | 18 | 60/80 |
| Patient 15/male/69/1 | astrocytoma, grade II | the left frontal lobe of the brain | tumor resection, chemo- and radiotherapy | 13 | N/A | N/A | 60/80 |
| Patient 16/female/53/1 | astrocytoma, grade II | the parietal lobe of the brain | tumor resection, chemo- and radiotherapy | 3/N/A/N/A/0 | N/A | 23 | 80/80 |
| Patient 5 /male/21/2 |
astrocytoma, grade III (relapse) | the left frontal, parietal, and temporal lobes of the brain, left lateral ventricle, visual hillock | tumor resection (2 times), chemo- and radiotherapy | 36/1/7 | 7/2 | 13 | 80/90 40/70 |
| Patient 6/female/67/1 | astrocytoma, grade III (relapse) | the left temporal and parietal lobes left lateral ventricle | tumor resection | 34/N/A/N/A/<1000 | 6 | 7 | 30/40 |
| Patient 9/male/42/1 | astrocytoma, grade III | the left parietal, occipital and temporal lobe of the brain, spreading to the lateral ventricle, mediobasal parts of the left frontal lobe | tumor resection, chemo- and radiotherapy | 55 | 9 | 10 | 80/80 |
| Patient 13/female/57/1 | astrocytoma, grade III | the frontal lobe of the brain | tumor resection, chemo- and radiotherapy | 29/N/A/N/A/<1000 | N/A | 5 | 60/60 |
| Patient 4 /female/42/2 |
astrocytoma, grade IV (GBM) (relapse) |
the right parietal lobe, right lateral ventricle, middle parts of the corpus callosum | tumor resection (2 times), chemo- and radiotherapy, gamma knife | 119 | 5 | 13.5 | 30/30 |
| Patient 8/female/72/1 | astrocytoma, grade IV (GBM) | deep departments of the left temporal lobe. | tumor resection, chemo- and radiotherapy | 68 | 5 | 9 | 60/60 |
| Patient 10/female/39/2 | astrocytoma, grade IV (GBM) | the left parietal, occipital, and temporal lobes of the brain, extending into the lateral ventricle, the medio-different sections of the left frontal lobe | tumor resection, chemo- and radiotherapy, gamma knife | 27/0/2 | 38 | 50 | 60/80 |
| Patient 11/male/63/2 | astrocytoma, grade IV (GBM) | the right parietal lobe of the brain | tumor resection | 31 | N/A | 3 | 40/40 |
| Patient 17/male/67/3 | astrocytoma, grade IV (GBM) | the left frontal lobe | tumor resection | 98 | 0.5 | 1 | 30/30 |
GBM, glioblastoma multiforme; N/A, no data available.