Table 1.

Summary of the GWAS datasets used in the current study

Phenotype	N cases	N controls	N total	N effective a	GWAS genome-wide significant SNPsb	References
IBS	53,400	433,201	486,601	190,159	6	[18]
Neuroticism	–	–	390,278c	390,278	136d	[20]
Depression	170,756	329,443	500,199c	449,856	102d	[21]
Anxiety nerves or GAD	16,730	101,021	117,751	57,412	1	UKBB phenotype code: 20544_15

GAD generalized anxiety disorder; UKBB UK Biobank

^aN effective sample sizes were calculated following the equation: Neff = 4/(1/Ncases + 1/Ncontrols)

^bNumber of genome-wide significant independent SNPs

^cSample size excluding the 23andMe cohort

^dGenome-wide significant SNPs including the 23andMe cohort