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. 2023 Apr 20;25:44. doi: 10.1186/s13058-023-01615-6

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — RAD51, miR-214-5P and miR-142-3P are differentially regulated between EA and AA TNBC samples. A Expression of RAD51 in AA (n = 26) and EA (n = 26) TNBC patients was analyzed by RT-PCR in two independent experiments in triplicate. B, C Expression of RAD51 in AA (n = 5) and EA (n = 5) TNBC patients analyzed by IHC in three independent experiments. D List of the top 30 miRNAs that were differentially regulated in racially different TNBC cell lines [AA (MDAMB468 and HCC1806) and EA (MDAMB231 and MDAMB453)]. E Volcano plot analysis of the miRNA-seq data based on the fold change and p-values in racially different TNBC cell lines [AA (MDAMB468 and HCC1806) and EA (MDAMB231 and MDAMB453)]. F Seed sequence in RAD51 to bind with miR-214-5P and miR-142-3P. G Expression of miR-142-3P in AA (n = 16) and EA (n = 16) TNBC patients analyzed by RT-PCR in two independent experiments with triplicates. H Expression of miR-214-5P in AA (n = 16) and EA (n = 16) TNBC patients analyzed by RT-PCR in two independent experiments in triplicate. I miR-214 expression in breast cancer patients with different racial backgrounds. (*p < 0.05) and (**p < 0.01)