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. 2023 Apr 20;25:44. doi: 10.1186/s13058-023-01615-6

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — miR-214-5P mimic downregulates RAD51 and synergizes with olaparib. A Comet assay representative images of MDAMB468 cells transfected with miR-control or miR-214-5P and treated with or without 25 µM olaparib for 24 h. B MDAMB468 and C HCC1806 analysis of comet tail area in more than 25 cells from three different experiments with their standard deviation as the error bars. D High-density colony assay plates of HCC1806 cells transfected with miR-control or miR-214-5P and treated with different concentrations of olaparib. E Low-density colony assay plates of MDAMB468 cells transfected with miR-control or miR-214-5P and treated with varying concentrations of olaparib. F Survival fraction of MDAMB468 cells transfected with miR-control or miR-214-5P and treated with varying concentrations of olaparib in three independent experiments. G Survival fraction of HCC1806 cells transfected with miR-control or miR-214-5P and treated with varying concentrations of olaparib in three independent experiments