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. Author manuscript; available in PMC: 2023 Apr 21.
Published in final edited form as: Psychopharmacology (Berl). 2020 Aug 10;237(12):3553–3568. doi: 10.1007/s00213-020-05635-4

Fig. 4. B6 TH-Cre+ mice display normal novelty-induced activity, AMPH-induced locomotion and AMPH and SKF-38393-induced stereotypic and grooming behaviors.

Fig. 4

(a) Experimental timeline. (b) B6 TH-Cre+ mice show comparable novelty-induced locomotion to B6 TH-Cre− control mice [curve–fit analysis, t = 0–30; F (4, 112) = 1.939, P = 0.1089, n = 9–11] and display habituation to the open field chamber [B6 TH-Cre, 2-way RM ANOVA; time F (3.593, 64.67) = 49.37, P < 0.0001, genotype F (1, 18) = 1.557, P = 0.2281, time x genotype interaction F (5, 90) = 0.8312, P = 0.5309 n = 9–11]. (c, d, e) Locomotor responses of B6 TH-Cre+ mice to low (1.8), moderate (3.0) and high (5.6 mg/kg) AMPH doses do not differ from B6 TH-Cre− control mice’ responses. [curve–fit analysis, t = 5–60; low: F (4, 232) = 1.950, P = 0.1030; moderate: F (4, 232) = 0.8037, P = 0.5239; high: F (4, 232) = 0.1855, P = 0.9458, n = 9–11]. (f) AMPH-induced stereotyped behavior is not altered in B6 TH-Cre+ mice [2-way RM ANOVA; genotype F (1, 18) = 0.0038, P = 0.9515, time F (1, 18) = 0.7070, P = 0.4115, genotype by time interaction F (1, 18) = 0.05190, P = 0.8224, n = 9–11]. (g) SKF-38393 induced grooming behavior is not altered in B6 TH-Cre+ mice [2-way RM ANOVA; drug, F (1, 18) = 24.74, P < 0.0001; genotype, F (1, 18) = 0.01953, P = 0.8904, drug x genotype interaction F (1, 18) = 0.1207, P = 0.7323, n = 9–11].