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[Preprint]. 2023 May 2:2023.04.11.536376. Originally published 2023 Apr 12. [Version 2] doi: 10.1101/2023.04.11.536376

Figure 2. Repeated loading in Young mice results in disruption of structural toughening mechanisms at enthesis.

Figure 2.

Repeated loading resulted in (A) opening of the calcaneal growth plate, (B) disruption of enthesis tidemark, reduction of subchondral bone mineralization, and vascular infiltration, in Young enthesis and apophyses. (C) Young and Adult loaded apophyses had significantly lower BMD compared to age-matched controls. Structural adaptations in the Young enthesis and apophysis, coincides with (D, E) significantly less tensile strength and toughness in the loaded compared to non-loaded contralateral limbs. Star specifies the opening of the calcaneal growth plate. Scale bars denote (A) 500μm and (B) 100μm. (*: p< 0.0.5, **: p< 0.001, ****: p < 0.0001, and ***: p = 0.0004).