Skip to main content
[Preprint]. 2023 Apr 13:2023.04.12.536558. [Version 1] doi: 10.1101/2023.04.12.536558

Figure 1. FGF-21 promotes renal gluconeogenesis under conditions of metabolic stress.

Figure 1.

(A)-(B) Renal glucose production increases in fasting (n=5 per group) and diabetic ketoacidosis (n= 6 per group) in mice. (C) Renal gluconeogenic gene expression increases in humans with diabetic nephropathy (n=3 per group). (D) Renal glucose production increases in a mouse model of NASH. (E) Liver Fgf21 expression in humans with NAFLD (n=72, vs. n=6 healthy controls). (F)-(G) Recombinant FGF-21 infusion increases renal glucose production in rats (n=6 per group). (H)-(I) Hepatic and renal glucose production in 24 hour fasted liver-specific FGF-21 KO mice (n=3 per genotype). (J) Blood glucose concentrations (n=3 per genotype). In all panels, *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 by the 2-tailed unpaired Student’s t-test (panels A-B, D, H-J) or by ANOVA with Tukey’s multiple comparisons test (panels F-G). P-values for gene expression (panel E) were adjusted for multiple comparisons.