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(A) Plasma FGF-21, (B) Plasma insulin, and (C) Plasma total bile acids in mice treated with an Fc-fused FGF-21 c-terminal peptide. (D) Plasma total bile acids in rats fasted for 8 or 48 hours, and 8 hr fasted rats infused with FGF-21. In all panels, n=5 per group. **P<0.01.
