Extended Data Figure 6. Renal gluconeogenesis is a targetable, pathogenic factor in murine models of RCC.

(A) Patients with low Slc2a1 and high cytosolic Pck1 expression (i.e. low glucose uptake through GLUT1 and high glucose production facilitated by PC expression at the transcriptional level) have poorer survival as compared to patients with high Slc2a1 and low Pck1 expression in tumor⁴³ (n=67 low Slc2a1 and high Pck1, vs. 32 high Slc2a1 and low Pck1). Unfortunately, expression data from surrounding parenchyma are not available. In panels (A) and (B), “low” and “high” were defined as falling in both the upper and lower, or lower and upper quartile of expression of the genes of interest. (B) Patients with low Atgl (Pnpla2) and Adrb2 expression in RCC tumors (n=60) have worse survival than patients with high Atgl (Pnpla2) and Adrb2 expression in RCC tumors (n=82). (C) Survival of RCC patients whose tumors express low Adrb2, low Atgl, and low Pck 1 (n=27) vs. those whose tumors express high Adrb2, high Atgl, and high Pck 1 (n=13).