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[Preprint]. 2023 Apr 13:2023.04.12.536558. [Version 1] doi: 10.1101/2023.04.12.536558

Figure 2. FGF-21 promotes renal gluconeogenesis via Adrb2-dependent neural hardwiring.

Figure 2.

(A)-(B) Endogenous glucose production from liver and kidney, and the fractional contribution of the kidney to total glucose production in rats administered an ICV infusion of FGF-21 (n=4 vehicle and 5 FGF-21). (C)-(D) Endogenous glucose production, and the renal contribution to whole-body glucose production in Klbf/f;Camk2a-Cre mice (n=6 per genotype). (E)-(F) Endogenous glucose production, and the renal contribution to whole-body glucose production in 6 hr fasted mice infused with FGF-21 and pretreated with an Adrb1 or Adrb2 antagonist, or vehicle (n=6 vehicle, 5 Adrb1 antagonist, and 6 Adrb2 antagonist). (G)-(H) Endogenous glucose production, and the renal contribution to whole-body glucose production in Adrb2 knockout mice infused with FGF-21 (n=4 vehicle-treated in both genotypes, and 5 FGF-21-treated in both genotypes). In all panels, **P<0.01, ***P<0.001, ****P<0.0001 by the 2-tailed unpaired Student’s t-test.