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[Preprint]. 2023 Apr 13:2023.04.12.536558. [Version 1] doi: 10.1101/2023.04.12.536558

Figure 5. FGF-21-dependent Adrb2 activity promotes renal glucose production in mice with RCC.

Figure 5.

(A)-(C) Glucose production and blood glucose concentrations in Renca tumor-bearing mice treated with a Fc-fused FGF-21 c-terminal peptide (n=5 per group). (D) Glucose production in murine Renca and surrounding kidney samples (n=4 tumor and 4 surrounding kidney). (E) Glucose production in human RCC tumor and surrounding parenchyma (n=10). (F) Glucose production in human RCC parenchyma treated with clenbuterol or vehicle (n=5). In panels (E) and (F), the paired t-test was used because samples from the same patients were compared. In all panels, *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.