Table 1:
Candidate genes for multiple neurodegenerative diseases. This table shows genes with functional inferences passing multiple test corrections for multiple neurodegenerative diseases. We provide details for all the omics and diseases in which a given gene has significant associations. Bolded genes indicate colocalized genes.
| Gene | Diseases | Omics |
|---|---|---|
| ARL17B | AD, PD | Cerebellum eQTL, Cortex eQTL, Spinalcord eQTL |
| KAT8 | AD, PD | Cerebellum eQTL, Whole Brain meta-analysis mQTL, Cerebellar Hemisphere eQTL, Cortex eQTL, Tibial Nerve eQTL, Skeletal Muscle eQTL, Hypothalamus eQTL, Whole Brain eQTL, Cerebellum eQTL, Spinalcord eQTL |
| LRRC37A2 | AD, PD | Hippocampus eQTL, Cortex eQTL, Frontal Cortex BA9 eQTL, Prefrontal Cortex eQTL, Caudate Basal Ganglia eQTL, Skeletal Muscle eQTL, Multi Ancestry, Whole Brain Meta-analysis eQTL, Hypothalamus eQTL, Liver eQTL, Anterior Cingulate Cortex BA24 eQTL, Putamen Basal Ganglia eQTL, Amygdala eQTL, Whole Brain eQTL, Cerebellum eQTL, Nucleus Accumbens eQTL, Basal Ganglia eQTL, Spinalcord eQTL, Hippocampus eQTL, Substantia nigra eQTL |
| KANSL1 | AD, PD, PSP | Whole Brain meta-analysis mQTL, Whole Blood mQTL, Cortex eQTL, Multi Ancestry Whole Brain Meta-analysis eQTL, Spinalcord eQTL, Anterior Cingulate Cortex BA24 eQTL |
| ARL17A | AD, PD, PSP | Spinalcord eQTL, Amygdala eQTL, Multi Ancestry Whole Brain Meta-analysis eQTL, Hypothalamus eQTL, Hippocampus eQTL, Cerebellar Hemisphere eQTL, Cortex eQTL, Caudate Basal Ganglia eQTL, Anterior Cingulate Cortex BA24 eQTL, Putamen Basal Ganglia eQTL, Cerebellum eQTL, Nucleus Accumbens Basal Ganglia |
| PRSS36 | AD, PD | Whole Brain meta-analysis mQTL, Cortex eQTL, Cerebellar Hemisphere eQTL, Multi Ancestry Whole Brain Meta-analysis eQTL, Whole Brain eQTL |
| MAPT | AD, PD, PSP | Whole Brain meta-analysis mQTL, Whole Blood mQTL |
| IDUA | LBD, PD | Whole Brain meta-analysis mQTL, Whole Blood mQTL, Whole Blood eQTL(eQTLgen) |
| TMEM175 | LBD, PD | Whole Blood mQTL |
| ARHGAP27 | AD, PD, PSP | Whole Blood mQTL, Whole Blood eQTL (eQTLgen), Multi Ancestry Whole Brain Meta-analysis eQTL, Caudate Basal Ganglia eQTL, Nucleus Accumbens Basal Ganglia |
| CRHR1 | AD, PD, PSP | Whole Brain meta-analysis mQTL, Whole Blood mQTL, Cortex eQTL, Skeletal Muscle eQTL |
| FMNL1 | AD, PSP | Multi Ancestry Whole Brain Meta-analysis eQTL, Whole Blood mQTL |
| PLEKHM1 | PD, PSP | Cortex eQTL, Frontal Cortex BA9 eQTL, Prefrontal Cortex eQTL, Caudate Basal Ganglia eQTL, Skeletal Muscle eQTL, Anterior Cingulate Cortex BA24 eQTL, Putamen Basal Ganglia eQTL, Whole Brain eQTL |
| WNT3 | AD, PD | Cortex eQTL metaBrain, Skeletal Muscle eQTL, Tibial Nerve eQTL |
| SPPL2C | AD, PD | Cerebellum eQTL, Prefrontal Cortex eQTL |